Open Positions

1

Time Span

as soon as possible for 3 years

Application Deadline

14 Mar 2025

Financing

yes

Areas of study

Biology, Biochemistry, Chemistry, Human Biology, Biomedicine

Description

Better together. For life.   
At the University Medical Center Hamburg-Eppendorf (UKE), we are committed to excellence in research, education, and comprehensive healthcare across our clinics. Every day, our team of approximately 15,300 dedicated employees works to make the world a healthier place. Our goal is to be one of the leading university hospitals while also being the best employer in our industry.

At UKE, we believe that meaningful and successful work should align with our employees' personal needs and individual lifestyles. Just as diverse as these needs are, so too is the variety of personalized solutions we offer. 
Welcome to the UKE.

Main tasks

Cancer undergoes a complex parasitic evolution, continuously evading immune system detection while orchestrating profound changes in its surrounding microenvironment, referred to as the tumor microenvironment (TME). Beyond intrinsic tumor factors, host-related elements—such as the microbiota, microbiota-derived metabolites, diet, and hormones—collectively known as the macroenvironment, play a pivotal role in shaping the TME and potentially exacerbating cancer progression.

This research project will investigate how the immune system is bidirectionally influenced by both the microenvironment and macroenvironment during carcinogenesis and therapy. By leveraging state-of-the-art multi-omics techniques—including single-cell sequencing, spatial transcriptomics, shotgun metagenomic sequencing, and metabolomic screening—alongside advanced murine cancer models and in vitro systems, we aim to elucidate the intricate interplay between the TME and the macroenvironment in driving cancer progression and therapy resistance. This project builds on previous studies, such as Tintelnot et al., Nature 2023, and Tintelnot et al., Cancer Immunology Research 2024.

We are seeking a motivated and innovative candidate with a passion for science and the curiosity to think creatively and push boundaries. The primary goal of this position is to advance our understanding of the tumor macro- and microenvironment and its influence on the immune system in the context of cancer. Your expertise will be instrumental in uncovering the molecular mechanisms driving cancer progression and therapy resistance, with the ultimate aim of translating these insights into clinical benefits for patients.

This position is temporary for three years in accordance with WissZeitVG and to be filled with 65 % of the regular weekly working hours.

Your Profile

• Completed academic studies in chemistry, biology, biochemistry, human biology, physiology, immunology or related subjects
• Profound knowledge in either chemistry (drug design, chemichal modification of metabolites), immunology, microbiota, cancer biology or cancer metabolism
• Prior knowledge in bioinformatic analysis of multi-omic data and/or work with laboratory mice is a plus
• High degree of intrinsic motivation

Immunity status

Please note that employment is contingent upon proof of immunization or immunity against the measles virus, in accordance with applicable legal and medical requirements. Documentation (e.g., vaccination certificate) must be provided before employment begins.

Our Offer

• Attractive compensation according to TVöD/VKA
• Secure employment with meaningful work and respectful collaboration
• Comprehensive onboarding and open knowledge exchange within the team
• Extensive training and further education programs at our UKE Academy for Education and Careers
• Opportunities to contribute to our “UKE INside” personnel policy through cross-professional and cross-hierarchical projects
• Sustainable travel: subsidies for the Deutschlandticket as a job ticket, and Dr. Bike bicycle service
• Family-friendly working environment: cooperation on childcare, free vacation childcare, advice for employees with relatives in need of care
• Excellent health, wellness, and sports programs
• A wide range of dining options in our staff restaurant, with additional choices available at the “Health Kitchen” cafés, bistros, and an on-site supermarket
• Access to cutting-edge technologies and equipment
• Weekly one-on-one meetings with the PI to ensure guidance and progress
• Access to human material for translational studies and a range of sophisticated mouse models (germ-free mice, cancer models, immune cell reporter mice), as well as advanced multi-omics platforms (single-cell sequencing, metabolomic screening, shotgun metagenomics) and corresponding bioinformatics pipelines
• Daily scientific exchange through lab meetings, topic meetings, and journal clubs
• A strong national and international collaboration network
• A dynamic, interdisciplinary team of scientists from diverse fields including medicine, biology, microbiology, and physiology

Contact

Contact to the department

Dr. Joseph Tintelnot

j.tintelnot@uke.de

Recruiting contact

Recruiting Team

+49 (0) 40 7410-52599

About us

We live diversity and value variety

We offer a work environment that provides equal opportunities regardless of age, gender, sexual identity, disability, ethnic and social origin, or religion. This is confirmed by our accession to the Charter of Diversity. We explicitly aim to increase the proportion of women in management positions, especially among scientific personnel in research and teaching. Women with equal qualifications will be given priority. The same applies in the case of under-representation of one gender in the advertised area. Persons with severe disabilities with equal aptitude, competence, and professional performance will be given priority.

> Learn more about "Diversity at UKE" here.